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ChemInform Abstract: Synergistic Effect of 5-Nitro-2′-deoxyuridine with Ganciclovir Against Human Cytomegalovirus in vitro.
First published: April 16, 1996
Abstract
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ChemInform Abstract
Practical syntheses of anomerically pure 5-nitro-2′-deoxyuridines (cf. (VII)) and the hitherto unknown arafluoro nucleoside (X) and analyses of their in vitro anti-HCMV activity alone and in combination with ganciclovir are reported. It is found that uridine (VII) causes a synergistic enhancement of the overall antiviral efficacy of the two agents.
