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ChemInform Abstract: Generation of Polyclonal Catalytic Antibodies Against Cocaine Using Transition State Analogues of Cocaine Conjugated to Diphtheria Toxoid.

G. P. BASMADJIAN,

G. P. BASMADJIAN

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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S. SINGH,

S. SINGH

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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B. SASTRODJOJO,

B. SASTRODJOJO

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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B. T. SMITH,

B. T. SMITH

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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K. S. AVOR,

K. S. AVOR

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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F. CHANG,

F. CHANG

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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S. L. MILLS,

S. L. MILLS

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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T. W. SEALE,

T. W. SEALE

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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G. P. BASMADJIAN,

G. P. BASMADJIAN

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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S. SINGH,

S. SINGH

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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B. SASTRODJOJO,

B. SASTRODJOJO

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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B. T. SMITH,

B. T. SMITH

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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K. S. AVOR,

K. S. AVOR

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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F. CHANG,

F. CHANG

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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S. L. MILLS,

S. L. MILLS

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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T. W. SEALE,

T. W. SEALE

Dep. Med. Chem. Pharm., Univ. Okla. Health Sci. Cent., Oklahoma City, OK 73117, USA

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First published: April 16, 1996

https://doi.org/10.1002/chin.199616254

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Abstract

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ChemInform Abstract

Starting from the cocaine derivative (I), six new transition state analogues (IIIb), (IV), (V), (VII), (IX), and (XI) and one non-tropane analogue (XIII) are prepared and their biological activities are tested.