ChemInform Abstract: A Series of (4-Arylbutadienyl)oxazolochromones with Highly Potent 5- Lipoxygenase Inhibitory Activity.
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract
A series of the title oxazolochromones (cf. (VIIc), (VIII)) are synthesized based on a Horner-Wadsworth-Emmons reaction and evaluated for their 5-lipoxygenase inhibitory activity. Several members of this series are more potent than TMK-777, which represents one of the most potent 5-lipoxygenase inhibitors so far known. The 3′,4′- dihydroxyphenyl derivative (cf. (VIII)) shows the highest potency in both ester and carboxylic acid form.
