ChemInform Abstract: Biosynthesis of the Hypotensive Metabolite Oudenone (IIb) by Oudemansiella radicata. Part 1. Intact Incorporation of a Tetraketide Chain Elongation Intermediate.
Abstract
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ChemInform Abstract
The successful microbiological incorporation of the deuterated tetraketide (I) into (IIa) establish that the title metabolite (IIb) is composed from six acetate units. A biosynthetic scheme and cyclization mechanism, consistent with the experimental data, is proposed.