ChemInform Abstract: An Efficient, Safe, and Convenient One-Step Synthesis of β- Phenethylamines via Reductive Amination Reactions Utilizing Ti(OiPr)4 and NaBH4.
Abstract
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ChemInform Abstract
The reductive amination of benzylic ketones and aldehydes with titanium(IV) isopropoxide and sodium borohydride provides a simple, mild and high-yielding procedure for the synthesis of β- phenethylamines (10 examples).