Volume 27, Issue 11
Isocyclic Compounds
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ChemInform Abstract: An Efficient, Safe, and Convenient One-Step Synthesis of β- Phenethylamines via Reductive Amination Reactions Utilizing Ti(OiPr)4 and NaBH4.

S. BHATTACHARYYA

S. BHATTACHARYYA

Dep. Chem., Univ. Miss., University, MS 38677, USA

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A. CHATTERJEE

A. CHATTERJEE

Dep. Chem., Univ. Miss., University, MS 38677, USA

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J. S. WILLIAMSON

J. S. WILLIAMSON

Dep. Chem., Univ. Miss., University, MS 38677, USA

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First published: March 12, 1996

Abstract

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ChemInform Abstract

The reductive amination of benzylic ketones and aldehydes with titanium(IV) isopropoxide and sodium borohydride provides a simple, mild and high-yielding procedure for the synthesis of β- phenethylamines (10 examples).

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