ChemInform Abstract: Highly Efficient Enantioselective Pauson-Khand Reactions.
Abstract
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ChemInform Abstract
A range of cobalt-alkyne complexes containing the chiral ligand (II) are synthesized. The diastereomers thus obtained are separated chromatographically. The isolated, optically pure diastereomeric complexes are employed in intermolecular Pauson-Khand reactions using N-methylmorpholine N-oxide as promotor to give high yields of cyclopentenone products such as (IV) from (III) in excellent enantiomeric excesses. Examples are also given with norbornadiene and the reactions with both alkenes proceed to give only the exo- cyclopentenone products.
