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ChemInform Abstract: A New Method for Hydroxymethylene Peptide Isostere Synthesis: Asymmetric Synthesis of Statine.
First published: May 9, 1995
Abstract
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ChemInform Abstract
The key step of the asymmetric synthesis of (-)-statine (IXa), an unusual amino acid occurring in the potent inhibitor of aspartic proteases pepstatin, is the coupling reaction of the hemi-acetal (V) with the ketene silyl acetal (VI). The method is suitable to be extended to the preparation of other peptidomimetics.
