ChemInform Abstract: New Preparation of N(1)- and N(2)-Alkylated Tetrazoles via Displacement of Activated Alcohols.
Abstract
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ChemInform Abstract
The displacement of activated alcohols by a tetrazole to give alkylated tetrazoles is investigated. This reaction is also applicable to epoxides. 5-Substituted tetrazoles, such as (VIII), form specifically one regioisomer. In case of cinnamyl alcohol a mixture of α- and γ-adducts is formed. The highly activated alcohol ( XI) reacts even in the absence of the catalyst.
