Heterocyclic Compounds
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ChemInform Abstract: Addition of Organometallic Reagents to N-Glycosyl Nitrones. Enantioselective Syntheses of (+)-(R)- and (-)-(S)-Zileuton.
First published: May 9, 1995
Abstract
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ChemInform Abstract
The enantiomers of the 5-lipoxygenase inhibitor zileuton (VIII) are synthesized via the common intermediate (III) by diastereoselective addition of organometallic reagents to the mannose-derived nitrones as key step.
