ChemInform Abstract: Carbon-Carbon Bond-Forming Methods on Solid Support. Utilization of Kenner′s “Safety-Catch” Linker.
Abstract
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ChemInform Abstract
A general and high-yielding method for the solid-phase synthesis of substituted arylacetic acid derivatives such as (IX) and (XI) (13 examples) is presented. The key carbon-carbon bond forming reactions in the synthesis sequence are enolate alkylation yielding (V) and palladium-mediated Suzuki cross-coupling using either (VI) or (X). Nucleophilic cleavage from the support can also be achieved with hydroxide forming carboxylic acids.
