Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Evaluation of N-Substituted 1-(5-Fluoro-2-pyrimidinyl) piperazine Derivatives as Potential anti-Ischemic Agents.
First published: February 28, 1995
Abstract
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ChemInform Abstract
A number of N-substituted piperazines, e.g. (VI) (no yieds given), are evaluated for binding to sigma and serotonin 5-HT1A and 5-HT2 receptor subtypes as well as for their protection against nitrogen anoxia induced lethality in rats. No correlation exists between receptor binding and in vivo effects.
