Volume 26, Issue 6
Natural Products
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ChemInform Abstract: The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne (I) to a Netropsin Analogue

M. F. SEMMELHACK

M. F. SEMMELHACK

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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J. J. GALLAGHER

J. J. GALLAGHER

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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W. DING

W. DING

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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G. KRISHNAMURTHY

G. KRISHNAMURTHY

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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R. BABINE

R. BABINE

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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G. A. ELLESTAD

G. A. ELLESTAD

Dep. Chem., Princeton Univ., Princeton, NJ 08544, USA

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First published: February 7, 1995

Abstract

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ChemInform Abstract

(attachment of the simple diyne (I) to a netropsin derivative as a model for the activity of natural ene diyne antibiotics; enhancement of the DNA cleavage potency by a factor of up to 2000).

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