Isocyclic Compounds
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ChemInform Abstract: Building Blocks for the Preparation of Enantiomerically Pure Drugs Containing a Phenylalkylamine Moiety.
First published: February 7, 1995
Abstract
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ChemInform Abstract
The isomeric ketols (II) and (III) are transformed to the chiral building blocks (IV) and (VII). Starting from the latter the spasmolytic amine (XII) is prepared. The opposite enantiomers of (IV) and (VII) can be synthesized from the diketone (I) via microbial reduction by Aspergillus niger.
