ChemInform Abstract: Synthesis of (-)-Bactobolin from D-Glucose and from (+)-Actinobolin.
Abstract
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ChemInform Abstract
Starting from (D)-glucose (I) or (+)-actinobolin (III) the synthesis of an important intermediate (X) for preparing enantiospecifically (-)- bactobolin (XI) (broad spectrum antibiotic with antitumor activity) is carried out. Key step is the diastereoselective addition of in-situ formed dichloromethyl lithium (VI) to the keto derivative (V) in the presence of cerium chloride via two different reaction pathways.
