Heterocyclic Compounds
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ChemInform Abstract: Potential Antimalarials. Part 20. Mannich Base Derivatives of 2-(7- Chloroquinolin-4-ylamino and 7-bromo(and 7-trifluoromethyl)-1,5- naphthyridin-4-ylamino)-4-chloro(or 4- or 6-t-butyl or 4- or 5-fluoro) phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino) phenol.
First published: October 4, 1994
Abstract
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ChemInform Abstract
Several Mannich base derivatives of the title compound are synthesized, e.g. (I), (II) and (III), and the antimalarial activities are tested in vitro. The most active compound is shown to be phenol (III).
