Volume 25, Issue 35
Heterocyclic Compounds
Full Access

ChemInform Abstract: Synthesis and Adrenergic Activities of Ring-Fluorinated Analogues of 2- (3,4-Dihydroxyphenyl)morpholine.

B.-H. CHEN

B.-H. CHEN

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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D. SHI

D. SHI

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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J. LUEDERS

J. LUEDERS

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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W. L. PADGETT

W. L. PADGETT

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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C. R. CREVELING

C. R. CREVELING

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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J. W. DALY

J. W. DALY

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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K. L. KIRK

K. L. KIRK

Lab. Bioorg. Chem., NIH, Bethesda, MD 20892, USA

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First published: August 30, 1994

Abstract

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ChemInform Abstract

Fluorine substitution does not have marked effects on adrenergic activities of dihydroxyphenyl morpholine derivatives. The results suggest that the presence of a side-chain hydroxyl group may be a key factor in fluorine-induced adrenergic activities.

chemical structure image

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