Volume 25, Issue 35
Heterocyclic Compounds
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ChemInform Abstract: 1,4-Diazabicyclo(2.2.2)octane (DABCO)-catalyzed Hydrolysis and Alcoholysis Reactions of 2-Amino-9-benzyl-6-chloro-9H-purine.

J. A. LINN

J. A. LINN

Div. Org. Chem., Burroughs Wellcome Co., Research Triangle Park, NC 27709, USA

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E. W. MCLEAN

E. W. MCLEAN

Div. Org. Chem., Burroughs Wellcome Co., Research Triangle Park, NC 27709, USA

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J. L. KELLEY

J. L. KELLEY

Div. Org. Chem., Burroughs Wellcome Co., Research Triangle Park, NC 27709, USA

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First published: August 30, 1994

Abstract

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ChemInform Abstract

The title compound (I) reacts by the use of DABCO in a mild and efficient process with hydroxide ion or alcohols such as (III) to 9- substituted guanines (II) and 6-alkoxy-purines (IV), respectively.

chemical structure image

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