ChemInform Abstract: Synthesis of 2′-Deoxy-2′-spirocyclopropyl Cytidine as Potential Inhibitor of Ribonucleotide Diphosphate Reductase.
Abstract
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ChemInform Abstract
Ribonucleoside diphosphate reductase appears to be a very attractive target for new anticancer agents and research has concentrated on a better understanding of its mechanism of action and the design of selective inhibitors. Based on the mechanism of action of the enzyme, a new class of nucleosides, the title compound (X), which may act as inhibitors is designed. The key step of the synthesis is the condensation with diazomethane giving a (separable) mixture of (VIII) and (IX).
