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ChemInform Abstract: Synthesis of 20-Deethylsilicine from a Second-Generation 2-Cyano-. delta.3-piperidine Synthon.
First published: April 6, 1993
Abstract
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ChemInform Abstract
Zn(II)-catalyzed reaction of the title synthon (II) with indole (I) gives the indolylmethyl(phenylsulfonyl)piperidinecarbonitrile (III). This is consecutively treated with AgBF4 and diethyl sodiomalonate (IV) to form the δ2-piperidine (V) which is subjected to catalytic hydrogenation and acid-mediated cyclization, yielding the target alkaloid derivative (VII).
