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ChemInform Abstract: Convergent Synthesis of (.+-.)-Dihydroisocodeine in 11 Steps by the Tandem Radical Cyclization Strategy. A Formal Total Synthesis of (.+-.) -Morphine.
First published: April 6, 1993
Abstract
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ChemInform Abstract
The synthesis of (.+-.)-dihydroisocodeine (VII), a precursor of morphine (VIII), proceeds via tandem cyclization of the aryl ether (IV) to give the tetracyclic styrene (V). The final bond connection is achieved by desulfonation of (V) which results in an unprecedented cyclization to afford the morphine ring system (VI) directly.
