ChemInform Abstract: Synthesis and Evaluation of Analogues of Z-1-(4-Methoxyphenyl)-2-(3,4, 5-trimethoxyphenyl)ethene as Potential Cytotoxic and Antimitotic Agents.
Abstract
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ChemInform Abstract
Wittig reaction of the phosphonium bromides (I) with the benzaldehydes (II) yields the E- (III) and Z-stilbenes (IV) with the predominance of the latter. The related carboxylic acids (VII), prepared by coupling of the phenylacetic acid (V) with the benzaldehydes (VI), are converted to amides and esters such as (IXa) and (IXb). The syntheses of further stilbenes are described in the original paper. The compound (IVb) mentioned in the title shows the best cytotoxic activity in five human cancer cell lines.
