ChemInform Abstract: Formation of 2,5-Dihydro-3H-pyrazolo(4,3-c)quinolin-3-ones from Ethyl 3-Anilino-2-(2-tert-butyl-2H-tetrazol-5-yl)acrylates.
Abstract
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ChemInform Abstract
Coupling of the arylamines (I) with the tetrazole-substituted acrylate (II) forms the β-arylaminoacrylates (III) which are cyclized in refluxing diphenyl ether to form the pyrazolo-fused quinolinones (IV) mentioned in the title. A mechanism involving the loss of nitrogen is proposed. The tetrazole derivative (V) yields the tetrazolylquinolone ( VI) under these cyclization conditions.