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ChemInform Abstract: Isolation of an Isomer of FK-506 from Fermentation of Streptomyces tsukubaensis and Its Chemical Synthesis from FK-506.
First published: May 19, 1992
Abstract
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ChemInform Abstract
The title compound (III) is prepared from the silylated reduction product (I) of the immunosuppressant FK-506. The latter is in clinical evaluation for the prevention and treatment of organ transplant rejection.
