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ChemInform Abstract: Synthesis and Anticancer Activity of Various 3′-Deoxy Pyrimidine Nucleoside Analogues and Crystal Structure of 1-(3-Deoxy-β-D- threo-pentofuranosyl)cytosine.
First published: October 1, 1991
Abstract
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ChemInform Abstract
A series of 3′-deoxy pyrimidine nucleosides such as (II) are synthesized in multi-step syntheses starting with uridine (I). Some derivatives, e.g. (IIa) and (IIb), show significant antitumor activity against several cancer cell lines in vitro.
