ChemInform Abstract: Muscarinic Cholinergic Agonists and Antagonists of the 3-(3-Alkyl-1,2, 4-oxadiazol-5-yl)-1,2,5,6-tetrahydropyridine Type. Synthesis and Structure-Activity Relationships.
Abstract
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ChemInform Abstract
Reaction of the tetrahydro-3-pyridinecarboxylates (I) with amidoximes such as (II) forms the corresponding oxadiazolyl derivatives (III). The isomers (VIII) are prepared by reaction of the nitrile (IV) with hydroxylamine hydrochloride (V) followed by cyclization with the carboxylic anhydrides (VII). In biological tests mentioned in the title, the branched or cyclic derivatives (IIIc) are antagonists, whereas the unbranched compounds, e.g. (IIIb), are agonists.
