Heterocyclic Compounds
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ChemInform Abstract: Stereoselective Syntheses of Substituted γ-Lactams from 3- Alkenamides.
First published: October 1, 1991
Abstract
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ChemInform Abstract
Reaction of benzaldehyde (I) with the β,γ-unsaturated amides (II) or (VII) in polyphosphoric acid forms diastereoselectively the tricyclic lactams (III), (VIII), and (IX). Reaction of (I) with ( II) in methanesulfonic acid (IV) produces the lactam (V) which is cyclized in polyphosphoric acid to give (III) or the piperidone (VI) depending on the temperature applied.
