Preparative Organic Chemistry
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ChemInform Abstract: Selective Reduction of Disulfides by Tris(2-carboxyethyl)phosphine.
First published: October 1, 1991
Abstract
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ChemInform Abstract
Tris(2-cyanoethyl)phosphine (I) is hydrolyzed in hydrochloric acid to give tris(2-carboxyethyl)phosphine hydrochloride (II). This compound reduces preferentially more strained disulfides rapidly and quantitatively in water at pH 4.5. (Mechanism).
