ChemInform Abstract: Catalytic Antibodies with Acyl-Transfer Capabilities: Mechanistic and Kinetic Investigations.
Abstract
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ChemInform Abstract
An extended study is presented on three different monoclonal antibodies (2H6, 21H3 and 43C9) that catalyze the hydrolysis of an alkyl ester and an aryl amide bond. New substrates (I) and (II) are synthesized and buffer-assisted reactions are employed to determine antibody-substrate fidelity. The catalytic antibodies are shown to be extremely specific with respect to both substrate and nucleophile and will permit only little latitude in choice of potential substrates. 18O-incorporation experiments are performed providing evidence that these antibody-mediated reactions proceed through attack at the acyl carbonyl.
