Heterocyclic Compounds
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ChemInform Abstract: Potential Antipsychotic Agents. Part 5. Synthesis and Antidopaminergic Properties of Substituted 5,6-Dimethoxysalicylamides and Related Compounds.
First published: November 27, 1990
Abstract
The trimethoxybenzene (I) is converted into the substituted benzoic acids (II).
ChemInform Abstract
The trimethoxybenzene (I) is converted into the substituted benzoic acids (II). Consecutive treatment of (II) with SOCl2 and aminomethylpyrrolidine (III) leads to the formation of the methoxylated benzamides (S)-(IV) which are demethylated with BBr3 to yield a mixture of the isomers (S)-(V) and (S)-(VI).
