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ChemInform Abstract: Design and Synthesis of New 1,4-Diaminocyclitol Aminoglycosides: Use of Maltose as the Key Starting Material.
First published: September 11, 1990
Abstract
Starting from the maltose derivative (I) the cyclitol glycosides (VII) and (VIII) are prepared in a multi-step synthesis.
ChemInform Abstract
Starting from the maltose derivative (I) the cyclitol glycosides (VII) and (VIII) are prepared in a multi-step synthesis. The transformation of the 1,6-anhydrohexopyranose moiety into a cyclitol moiety is accomplished by thiolysis of the anhydro ring under formation of a thioglycoside, e.g. (V), with subsequent Ferrier carbocyclisation to the cyclitol, e.g. (VI). The deoxy analogue of (VII), i.e. (VIII), is prepared analogously from (IV).
