Organoelement Compounds
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ChemInform Abstract: An Organometallic Route for the Preparation of Ring-Substituted 2-Arylpropanoic and -butanoic Acids.
First published: September 11, 1990
Abstract
The ester (I) reacts with chromium hexacarbonyl (II) to form the arenechromium carbonyl complex (III), which is deprotonated and then alkylated with (IV), producing the 2-arylbutanoate complex (V).
ChemInform Abstract
The ester (I) reacts with chromium hexacarbonyl (II) to form the arenechromium carbonyl complex (III), which is deprotonated and then alkylated with (IV), producing the 2-arylbutanoate complex (V). This is demetalated by oxidation and subsequently saponified to yield the title compound (VI). Reaction of (III) with methyl iodide (VII) gives a 1:1 mixture of the mono- (VII) and the dimethylated complex (IX).
