ChemInform Abstract: Superoxide Dismutase-Like Activity of 1,2,3-Triazole Derivatives.

ChemInform Abstract

The 1,2,3-triazole (III) is prepared by cycloaddition reaction of the azide (I) with vinyl acetate (II), followed by bromination. The disulfide (V) is obtained upon treatment of (III) with potassium ethyl xanthate (IV). The sulfide (VIII) is formed from (VI) by reaction with sodium trithiocarbonate (VII). Treatment of (VI) with potassium ethyl xanthate (IV) yields the thioether (IX). The triazole (XII) is prepared by cyclization of (X) with acetylacetone (XI) and consecutive bromination. Subsequent coupling with potassium ethyl xanthate (IV) gives the dithiocarbonate (XIII). The compounds (V), (VIII), (IX), and (XIII) show superoxide dismutase-like activity equivalent to well known drugs against rheumathoid arthritis.