Heterocyclic Compounds
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ChemInform Abstract: Synthesis and Pharmacological Properties of 2-Nitro-3-Substituted-aminobenzo(b)thiophenes and 1-Substituted Benzothieno(2,3-d)imidazoles.
First published: September 11, 1990
Abstract
The aminobenzothiophenes mentioned in the title (III) are synthesized from the bromonitrobenzothiophene (I) and the amines (II).
ChemInform Abstract
The aminobenzothiophenes mentioned in the title (III) are synthesized from the bromonitrobenzothiophene (I) and the amines (II). Reductive cyclocondensation of (III) with triethyl orthoformate (IV) produces the fused imidazoles (V). The pharmacological investigation proves dose-related analgesic activities for (IIIa), (IIIb), and (IIId). Compound (IIIc) is inactive. The antiexudative responses, the ulcerogenic potential, and LD50-values for (III) are determined. The compounds (V) do not show any analgesic or antiinflammatory activities. (No yields given).
