Isocyclic Compounds
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ChemInform Abstract: Potential Antidepressant and Antiinflammatory Agents: 4-(2-Propylthio)acetophenone Oximes and 4-(2-Propylthio)phenylalkanoic Acids.
First published: September 11, 1990
Abstract
The O-aminoalkyl derivatives (III) and (V) are analogues of the well-known antidepressant, agent "fluvoxamine" (VI).
ChemInform Abstract
The O-aminoalkyl derivatives (III) and (V) are analogues of the well-known antidepressant, agent "fluvoxamine" (VI). The acid (XIII) represents a thia isostere of the known antiinflammatory agent "ibuprofen" (XIV). The O-aminoalkyl derivatives (III) and (V) and the acids (VIII) and (XIII) are screened for their antidepressant antiinflammatory and analgesic activity. The fluvoxamine analogue (V) may be regarded as a potential antidepressant. The acids (VIII) and (XIII) have an antiinflammatory activity comparable to that of ibuprofen (XIV).
