Isocyclic Compounds
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ChemInform Abstract: Synthesis of 3-Alkylcatechols via Intramolecular Cyclization.
First published: September 11, 1990
Abstract
The alkanoylfurans (III) are prepared by coupling furfural (I) with the Grignard reagents (II) followed by oxidation with MnO2.
ChemInform Abstract
The alkanoylfurans (III) are prepared by coupling furfural (I) with the Grignard reagents (II) followed by oxidation with MnO2. Electrolysis of (III) in methanol (IV) and subsequent catalytic hydrogenation gives the dimethoxy derivatives (V). These are hydrolyzed with 0.1 N HCl to form the dioxoalkanals (VI). Using 1 N HCl, cyclization occurs, producing the alkylcatechols (VII).
