Preparative Organic Chemistry
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ChemInform Abstract: Diastereoselective Reduction of α,α-Difluoro β-Hydroxy Ketones to syn- and anti-2,2-Difluoro-1,3-diols.
First published: September 11, 1990
Abstract
The reduction of difluoro hydroxy ketones such as (I) with DIBAL gives mixtures of syn- and anti-diols, e.g. (II) + (III), in varying ratios.
ChemInform Abstract
The reduction of difluoro hydroxy ketones such as (I) with DIBAL gives mixtures of syn- and anti-diols, e.g. (II) + (III), in varying ratios. The reduction with DIBAL in the presence of ZnCl2-TMEDA or the Wagner-Meerwein-Ponndorf-Verley reduction, however, is highly selective leading to syn- or anti-diols, respectively.
