Isocyclic Compounds
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ChemInform Abstract: Reductive Cross Coupling Reaction of a Glyoxylate with Carbonyl Compounds. A Facile Synthesis of α,β-Dihydroxycarboxylate Based on a Low Valent Titanium Compound.
First published: March 27, 1990
Abstract
The aldehydes (I) are treated with a low valent titanium agent, generated from titanium tetrachloride and zinc copper couple, in DME/methylene chloride to produce the diols (II).
ChemInform Abstract
The aldehydes (I) are treated with a low valent titanium agent, generated from titanium tetrachloride and zinc copper couple, in DME/methylene chloride to produce the diols (II). Mixed coupling reactions of (Ia) with (Ib) or of (Ib) with the carbonyl derivatives (IV) are also performed. Optimum yields are obtained when the reactants are slowly added to the reducing mixture.
