Heterocyclic Compounds
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ChemInform Abstract: Alkyl Substituted 3-PPP Derivatives. Synthesis and Biological Investigation.
First published: January 2, 1990
Abstract
The title compounds (VI), (VII), (XIII), and (XVI) are alkylated derivatives of the known 3-PPP (VIII), a prototype dopamine autoreceptor agonist.
ChemInform Abstract
The title compounds (VI), (VII), (XIII), and (XVI) are alkylated derivatives of the known 3-PPP (VIII), a prototype dopamine autoreceptor agonist. Their synthesis is carried out as shown in the scheme in order to study the effects of substituents on the activity compared to (VIII). None of the compounds prepared are found to be more potent than (VIII). The ethyl derivative (VIb) is obtained similarly to (VIa).
