ChemInform Abstract: Ortho-Substitution of m-Anisaldehyde via α-Amino Alkoxide Directed Lithiation.
ChemInform Abstract
m-Anisaldehyde (I) is lithiated in the presence of the amine (II) and subsequently treated with methyl iodide (V) to give regioselectively the 2-methylated product (VI) via the intermediate (IV).