Volume 21, Issue 1
Isocyclic Compounds
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ChemInform Abstract: Ortho-Substitution of m-Anisaldehyde via α-Amino Alkoxide Directed Lithiation.

D. L. COMINS

D. L. COMINS

Dep. Chem. Biochem., Utah State Univ., Logan, UT 84322, USA

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J. D. BROWN

J. D. BROWN

Dep. Chem. Biochem., Utah State Univ., Logan, UT 84322, USA

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First published: January 2, 1990

ChemInform Abstract

m-Anisaldehyde (I) is lithiated in the presence of the amine (II) and subsequently treated with methyl iodide (V) to give regioselectively the 2-methylated product (VI) via the intermediate (IV).

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