ChemInform Abstract: Optimization of the Reaction Conditions Using a NADH Model Grafted on a Merrifield Type Resin.
Abstract
The synthesis of reducing agent (I), 1,4-dihydronicotinamide grafted on a Merrifield resin, through quaternization of nicotinamide with the Merrifield resin in refluxing MeCN followed by Na2S2O4 reduction, is described.
ChemInform Abstract
The synthesis of reducing agent (I), 1,4-dihydronicotinamide grafted on a Merrifield resin, through quaternization of nicotinamide with the Merrifield resin in refluxing MeCN followed by Na2S2O4 reduction, is described. The reaction conditions of reagent (I) are optimized with respect to the solvent and the catalyst amount. The substrate used for these studies is the aldehyde (II). The reagent (I) is more sensitive to traces of water than free NADH models such as (III). However in hyper-dry conditions, reagent (I) is very much more stable and more efficient.
