Heterocyclic Compounds
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ChemInform Abstract: One-Pot Synthesis of α-Mono- and α,α-Disubstituted Cyclic Ethers from Lactones.
First published: May 30, 1989
Abstract
The lactones (I) are coupled with the ethyl silyl ketene acetal (II) in the presence of Lewis acids and the silyl-substituted nucleophiles (III) to produce the ethoxycarbonylmethyloxacycloalkanes (IV).
ChemInform Abstract
The lactones (I) are coupled with the ethyl silyl ketene acetal (II) in the presence of Lewis acids and the silyl-substituted nucleophiles (III) to produce the ethoxycarbonylmethyloxacycloalkanes (IV). Various catalytic systems are tested. Optimum results are obtained using trityl hexachloroantimonate or a mixture of antimony pentachloride, chlorotrimethylsilane, and tin(II) iodide.
