Heterocyclic Compounds
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ChemInform Abstract: Preparation of New Nitrogen-Bridged Heterocycles. Part 19. Smooth Syntheses of Thieno(3,2-a)- and Thieno(2,3-b)indolizine Derivatives.
First published: May 30, 1989
Abstract
The cyclization of the indolizines (III), having an acyl and/or cyano group at the 1- and 3-positions, is examined under several alkaline conditions to yield the title compounds (IV)-(VII) in fairly good yields.
ChemInform Abstract
The cyclization of the indolizines (III), having an acyl and/or cyano group at the 1- and 3-positions, is examined under several alkaline conditions to yield the title compounds (IV)-(VII) in fairly good yields. The cyclization modes observed are in accordance with molecular orbital calculations using some model compounds and with stereochemical considerations of the starting indolizines. Various other examples are given.
