ChemInform Abstract: Synthesis of Substituted Tetrahydropyridines and m-Hydroxybenzoic Acids.
Abstract
With the ultimate objective of designing acyclic pro-drugs of the areca and ergot types, a series of substituted tetrahydropyridines such as (VII) and/or (VIII) is synthesized via intramolecular 1,6-Michael addition of amines such as (VI).
ChemInform Abstract
With the ultimate objective of designing acyclic pro-drugs of the areca and ergot types, a series of substituted tetrahydropyridines such as (VII) and/or (VIII) is synthesized via intramolecular 1,6-Michael addition of amines such as (VI). The amines (VI), in turn, can be prepared starting from a Wittig reaction of the readily obtainable aldehydes (II) via the intermediates (III) and (IV). In addition, a new route to m-hydroxybenzoic acids such as (IX) is established by cyclization of hexadienoic acids such as (IV).
