Preparative Organic Chemistry
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ChemInform Abstract: Applications of α-Alkoxyorganocuprate Reagents in the Regiospecific Synthesis of Cyclic Homoaldol Products.
First published: May 30, 1989
Abstract
A general route for the preparation of ca. 20 cyclic homoaldol products such as (VII) is described via conjugate addition of sec. and tert. substituted α-alkoxyorganocuprates derived from the stannanes (IV) to the non-sterically demanding enones (V).
ChemInform Abstract
A general route for the preparation of ca. 20 cyclic homoaldol products such as (VII) is described via conjugate addition of sec. and tert. substituted α-alkoxyorganocuprates derived from the stannanes (IV) to the non-sterically demanding enones (V). Most of the products are obtained as diastereomeric mixtures. Sterically demanding enones are less reactive or completely unreactive.
