Natural Products
Full Access
ChemInform Abstract: Facile Diacylation of Glycidyl Tosylate. Chiral Synthesis of Symmetric-Chain Glycerophospholipids.
First published: May 2, 1989
Abstract
Ring opening of the optically active epoxy alcohol (I) with stearic acid anhydride (II) gives the diacylated glycerol tosylate (IIIa) which is converted to the iodide (IIIb).
ChemInform Abstract
Ring opening of the optically active epoxy alcohol (I) with stearic acid anhydride (II) gives the diacylated glycerol tosylate (IIIa) which is converted to the iodide (IIIb). Reaction of (IIIb) with silver diphenyl phosphate (IV) produces the phosphorus acid ester (V) which is transformed into the diacylphosphocholine (VI) by standard procedures.
