Volume 20, Issue 18
Heterocyclic Compounds
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ChemInform Abstract: Biomimetic Ion Transport: A Functional Model of a Unimolecular Ion Channel.

V. E. CARMICHAEL

V. E. CARMICHAEL

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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P. J. DUTTON

P. J. DUTTON

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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T. M. FYLES

T. M. FYLES

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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T. D. JAMES

T. D. JAMES

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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J. A. SWAN

J. A. SWAN

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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M. ZOJAJI

M. ZOJAJI

Dep. Chem., Univ. Victoria, Victoria, B. C. V8W 2Y2, Can.

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First published: May 2, 1989

Abstract

A mixture of the regio- and stereoisomers of the macrocycle (VII) and its analogues obtained from (V) and (VIII) (instead of (IV)) is used to form a unimolecular ion channel.

ChemInform Abstract

A mixture of the regio- and stereoisomers of the macrocycle (VII) and its analogues obtained from (V) and (VIII) (instead of (IV)) is used to form a unimolecular ion channel. A large unilamellar vesicle with an imposed pH gradient shows a fast collapse in the presence of (VII). This effect is accelerated when a proton carrier is added.

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