Isocyclic Compounds
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ChemInform Abstract: Direct Lithiation of Hydroxyaromatics.
First published: May 2, 1989
Abstract
Lithiation of 2-naphthol (I) with tert-butyllithium and subsequent treatment with the electrophilic compounds (II) results in regioselective formation of the 3-substituted 2-naphthols (III).
ChemInform Abstract
Lithiation of 2-naphthol (I) with tert-butyllithium and subsequent treatment with the electrophilic compounds (II) results in regioselective formation of the 3-substituted 2-naphthols (III). In contrast, 1-naphthol (V) gives a mixture of the mono- and disubstituted 1-naphthols (VI) - (VIII). Anthrone (XI) reacts with dimethyl disulfide (IIb), yielding 1-methylthioanthrone (XII) and 1-methylthio-9,10-anthraquinone (XIII).
