Isocyclic Compounds
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ChemInform Abstract: Convenient Route to 1,3-Disubstituted Cyclobutanes: An Inexpensive Synthesis of 3-Oxocyclobutanecarboxylic Acid.
First published: February 7, 1989
Abstract
Cyclization of 1,3-dibromo-2,2-dimethoxypropane (I) with the anion derived from the malonates (II) yields the dimethoxycyclobutanedicarboxylates (III), together with the corresponding monoesters (IV).
ChemInform Abstract
Cyclization of 1,3-dibromo-2,2-dimethoxypropane (I) with the anion derived from the malonates (II) yields the dimethoxycyclobutanedicarboxylates (III), together with the corresponding monoesters (IV). Acidic cleavage of the acetal moiety is accompanied by ester hydrolysis and decarboxylation, producing the cyclobutanone carboxylic acid (V).
