Heterocyclic Compounds
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ChemInform Abstract: Radical Cyclizations onto 2(5H)-Furanone and Maleate Electrophores Leading to Spiro- and Linear-Fused γ-Lactone Ring Systems.
First published: January 10, 1989
Abstract
Dimethylmaleic anhydride (I) is reduced to give the 4-hydroxy-2-butenolide (II) and then converted to the ether (IV) which undergoes radical-induced cyclization, forming the bicyclic acetal (V).
ChemInform Abstract
Dimethylmaleic anhydride (I) is reduced to give the 4-hydroxy-2-butenolide (II) and then converted to the ether (IV) which undergoes radical-induced cyclization, forming the bicyclic acetal (V). This is oxidized with MCPBA to yield the fused bislactone (VI). Similar lactones such as (VIII) or (X) are prepared in an analogous manner.
