Isocyclic Compounds
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ChemInform Abstract: Acylamidation of Acetylenes.
First published: January 10, 1989
Abstract
The reaction between the alkynes (I), the nitriles (II) and acetyl tetrafluoroborate (III) proceeds regio- and stereospecifically by way of a syn-addition according to Markovnikov to afford the hitherto unknown Z-configurated N-acyl-β-amino-α,β-unsaturated ketones (III).
ChemInform Abstract
The reaction between the alkynes (I), the nitriles (II) and acetyl tetrafluoroborate (III) proceeds regio- and stereospecifically by way of a syn-addition according to Markovnikov to afford the hitherto unknown Z-configurated N-acyl-β-amino-α,β-unsaturated ketones (III). The Z configuration is unambiguously deduced from their IR spectra. Furthermore, these novel compounds are characterized by a strong intramolecular hydrogen bond.
